{"id":320,"date":"2022-07-26T18:25:54","date_gmt":"2022-07-26T18:25:54","guid":{"rendered":"https:\/\/ncds.sk\/?page_id=320"},"modified":"2022-07-26T18:40:19","modified_gmt":"2022-07-26T18:40:19","slug":"pricina-vzniku-t2dm","status":"publish","type":"page","link":"https:\/\/www.ncds.sk\/base\/?page_id=320","title":{"rendered":"Pr\u00ed\u010dina vzniku T2DM"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"320\" class=\"elementor elementor-320\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7e9de52 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7e9de52\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-09b73ae\" data-id=\"09b73ae\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4dcbbc7 elementor-widget elementor-widget-heading\" data-id=\"4dcbbc7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.5 - 27-04-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Oxid uhli\u010dit\u00fd: induktor civiliza\u010dn\u00fdch patol\u00f3gi\u00ed.<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-83cadb2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"83cadb2\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f61559d\" data-id=\"f61559d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9026fed elementor-widget elementor-widget-text-editor\" data-id=\"9026fed\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.5 - 27-04-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><em>Jusko P., Onkocet Ltd., Bratislava, Slovakia, 5. november 2014\u00a0<\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-bf521f9\" data-id=\"bf521f9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-de4f8f2 elementor-widget elementor-widget-eael-creative-button\" data-id=\"de4f8f2\" data-element_type=\"widget\" data-widget_type=\"eael-creative-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t        <div class=\"eael-creative-button-wrapper\">\n\n            <a class=\"eael-creative-button eael-creative-button--default\" href=\"#\" data-text=\"Go!\">\n\n                <div class=\"creative-button-inner\">\n\n                                            <span class=\"eael-creative-button-icon-left\"><i aria-hidden=\"true\" class=\"far fa-file-pdf\"><\/i><\/span>                    \n                    <span class=\"cretive-button-text\">PDF s\u00fabor: Pr\u00ed\u010dina vzniku patol\u00f3gie Diabetes Mellitus 2. typu.pdf<\/span>\n\n                                    <\/div>\n            <\/a>\n        <\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ae9b655 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ae9b655\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6053202\" data-id=\"6053202\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-78eb5f6 elementor-widget elementor-widget-heading\" data-id=\"78eb5f6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Abstrakt: Oxid uhli\u010dit\u00fd: induktor \u201eciviliza\u010dn\u00fdch\u201c patol\u00f3gii.<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-968110d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"968110d\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d7fc902\" data-id=\"d7fc902\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dfc4013 elementor-widget elementor-widget-text-editor\" data-id=\"dfc4013\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><em>Bolo zisten\u00e9, \u017ee nadmern\u00e1 hladina CO<sub>2<\/sub>\u00a0v\u00a0krvi vedie k\u00a0poru\u0161eniu rovnov\u00e1hy procesov z\u00fa\u010dast\u0148uj\u00facich sa na jeho tvorbe a regul\u00e1cii, \u010do m\u00e1 za d\u00f4sledok vznik patol\u00f3gii ako je diabetes mellitus II. typu, syst\u00e9mov\u00e1 hypertenzia, obezita, naru\u0161enie funkcie \u0161t\u00edtnej \u017e\u013eazy, at\u010f. Pr\u00ed\u010dinou zv\u00fd\u0161enej hladiny CO<sub>2<\/sub>\u00a0v\u00a0krvi s\u00fa predov\u0161etk\u00fdm bakteri\u00e1lno-hnilobn\u00e9 procesy prebiehaj\u00face v\u00a0hrubom \u010dreve.<\/em><\/p><p><strong>V\u00a0\u013eudskom organizme oxid uhli\u010dit\u00fd (CO<sub>2<\/sub>) vznik\u00e1 z\u00a0dvoch baz\u00e1lnych procesov:<\/strong><\/p><ol><li><strong>metabolick\u00fd<\/strong>\u00a0CO<sub>2<\/sub>\u00a0(CO<sub>2<\/sub>m) v procese spa\u013eovania cukrov v\u00a0bunk\u00e1ch org\u00e1nov a\u00a0tkan\u00edv organizmu<p><b><strong>C<sub>6<\/sub>H<sub>12<\/sub>O<sub>6<\/sub>(aq)\u00a0+ 6O<sub>2<\/sub>(g)\u00a0\u2014\u2014\u2014-&gt; 6CO<sub>2<\/sub>(g)\u00a0+ 6H<sub>2<\/sub>O(l) + ~38 ATP + teplo\u00a0 [1]<\/strong><\/b><\/p><div style=\"font-weight: bold; text-align: center;\"><span style=\"font-size: inherit; color: var(--color); font-family: var(--fontFamily); font-style: var(--fontStyle, inherit); font-weight: var(--fontWeight); letter-spacing: var(--letterSpacing); text-transform: var(--textTransform); text-align: center; background-color: var(--palettecolor7);\"><br \/>(teplo \u00a0\u0394G = \u22122880 kJ\/mol C<\/span><sub style=\"color: var(--color); font-family: var(--fontFamily); font-style: var(--fontStyle, inherit); font-weight: var(--fontWeight); letter-spacing: var(--letterSpacing); text-transform: var(--textTransform); text-align: center; background-color: var(--palettecolor7);\">6<\/sub><span style=\"font-size: inherit; color: var(--color); font-family: var(--fontFamily); font-style: var(--fontStyle, inherit); font-weight: var(--fontWeight); letter-spacing: var(--letterSpacing); text-transform: var(--textTransform); text-align: center; background-color: var(--palettecolor7);\">H<\/span><sub style=\"color: var(--color); font-family: var(--fontFamily); font-style: var(--fontStyle, inherit); font-weight: var(--fontWeight); letter-spacing: var(--letterSpacing); text-transform: var(--textTransform); text-align: center; background-color: var(--palettecolor7);\">12<\/sub><span style=\"font-size: inherit; color: var(--color); font-family: var(--fontFamily); font-style: var(--fontStyle, inherit); font-weight: var(--fontWeight); letter-spacing: var(--letterSpacing); text-transform: var(--textTransform); text-align: center; background-color: var(--palettecolor7);\">O<\/span><sub style=\"color: var(--color); font-family: var(--fontFamily); font-style: var(--fontStyle, inherit); font-weight: var(--fontWeight); letter-spacing: var(--letterSpacing); text-transform: var(--textTransform); text-align: center; background-color: var(--palettecolor7);\">6<\/sub><span style=\"font-size: inherit; color: var(--color); font-family: var(--fontFamily); font-style: var(--fontStyle, inherit); font-weight: var(--fontWeight); letter-spacing: var(--letterSpacing); text-transform: var(--textTransform); text-align: center; background-color: var(--palettecolor7);\">)<br \/><br \/><\/span><\/div><\/li><li><strong>bakteri\u00e1lno-hnilobn\u00e9<\/strong>\u00a0procesy prebiehaj\u00face v\u00a0d\u00f4sledku aktivity mikrobi\u00e1lnej fl\u00f3ry v\u00a0hrubom \u010dreve, ktor\u00e9 maj\u00fa za d\u00f4sledok tvorbu plynov ako CO<sub>2<\/sub>\u00a0(CO<sub>2c<\/sub>), H<sub>2<\/sub>, CH<sub>4<\/sub>\u00a0a\u00a0vy\u0161\u0161ie uh\u013eovod\u00edky, NH<sub>3<\/sub>, H<sub>2<\/sub>S a\u00a0in\u00e9 merkaptany.<\/li><\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d2a6478 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d2a6478\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ae70e22\" data-id=\"ae70e22\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e7cbb93 elementor-widget elementor-widget-text-editor\" data-id=\"e7cbb93\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Celkov\u00e1 hladina\u00a0<strong>CO<sub>2b<\/sub><\/strong>\u00a0v\u00a0krvi je teda s\u00fa\u010dtom metabolick\u00e9ho\u00a0<strong>CO<sub>2m<\/sub><\/strong>\u00a0a\u00a0<strong>\u00a0CO<sub>2c<\/sub><\/strong>\u00a0vznikaj\u00faceho v\u00a0hrubom \u010dreve.\u00a0<strong>CO<sub>2c<\/sub><\/strong>\u00a0vznikaj\u00faci v\u00a0hrubom \u010dreve sa za ur\u010dit\u00fdch okolnosti\u00a0m\u00f4\u017ee resorbova\u0165 do krvn\u00e9ho rie\u010di\u0161\u0165a. Mno\u017estvo\u00a0<strong>CO<sub>2c\u00a0<\/sub><\/strong>absorbovan\u00e9ho krvou z\u00e1vis\u00ed jednak od mno\u017estva CO<sub>2<\/sub>\u00a0produkovan\u00e9ho bakt\u00e9riami kolonizuj\u00facimi hrub\u00e9 \u010drevo, ako aj od hr\u00fabky filmu bakteri\u00e1lneho pokrytia sliznice hrub\u00e9ho \u010dreva.<\/p><p>\u00a0<\/p><p style=\"text-align: center;\"><strong>CO<sub>2b<\/sub>\u00a0= CO<sub>2m<\/sub>\u00a0+ CO<sub>2c<\/sub>\u00a0 [2]<\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b8e2f38 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b8e2f38\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-68eea12\" data-id=\"68eea12\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e394866 elementor-widget elementor-widget-text-editor\" data-id=\"e394866\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Parci\u00e1lny tlak kysl\u00edka a oxidu uhli\u010dit\u00e9ho (PO<sub>2<\/sub>\u00a0a PCO<sub>2<\/sub>) v arteri\u00e1lnej krvi \u010dloveka a zvierat je udr\u017eiavan\u00fd na pomerne stabilnej \u00farovni, aj napriek zna\u010dn\u00e9mu kol\u00edsaniu objemu O<sub>2<\/sub>\u00a0pri spotrebe a elimin\u00e1cii CO<sub>2<\/sub>. Hladina oboch plynov mus\u00ed by\u0165 teda neust\u00e1le pod pr\u00edsnou kontrolou. Hypotalamus, hlavn\u00fd regul\u00e1tor chemick\u00fdch procesov organizmu, prij\u00edma prim\u00e1rne sign\u00e1ly o\u00a0stave hladiny O<sub>2<\/sub>\u00a0a\u00a0CO<sub>2<\/sub>\u00a0prostredn\u00edctvom neur\u00e1lnej siete od mal\u00e9ho, ale ve\u013emi \u0161pecifick\u00e9ho org\u00e1nu nach\u00e1dzaj\u00faceho sa na bifurk\u00e1cii art\u00e9ri\u00ed, chemoreceptora s n\u00e1zvom karot\u00eddne teliesko. Preto procesy, ktor\u00e9 naru\u0161ia v\u00a0organizme homeost\u00e1zu\u00a0kysl\u00edka a oxidu uhli\u010dit\u00e9ho, m\u00f4\u017eu vies\u0165 k\u00a0syst\u00e9mov\u00fdm patofyziologick\u00fdm zmen\u00e1m.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-66cf696 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"66cf696\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3b09930\" data-id=\"3b09930\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div 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.elementor-divider-separator>.elementor-divider__svg:first-of-type{-webkit-box-flex:0;-ms-flex-positive:0;flex-grow:0;-ms-flex-negative:100;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{-webkit-box-flex:0;-ms-flex-positive:0;flex-grow:0;-ms-flex-negative:100;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-top:var(--divider-border-width) var(--divider-border-style) 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100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-697027f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"697027f\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cfd223f\" data-id=\"cfd223f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-08de84e elementor-widget elementor-widget-heading\" data-id=\"08de84e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-small\">Hypot\u00e9za: nadmern\u00e1 hladina CO2 v krvi vedie k poru\u0161eniu rovnov\u00e1hy procesov z\u00fa\u010dast\u0148uj\u00facich sa na jeho tvorbe a regul\u00e1cii.<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-660bd4a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"660bd4a\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-159878f\" data-id=\"159878f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3933454 elementor-widget elementor-widget-text-editor\" data-id=\"3933454\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Zv\u00fd\u0161en\u00e1 hladina CO<sub>2<\/sub>\u00a0(hyperkapnia) v\u00a0krvi PCO<sub>2<\/sub>\u00a0vedie k\u00a0cel\u00e9mu radu patol\u00f3gi\u00ed, ktor\u00e9 dnes modern\u00e1 medic\u00edna ozna\u010dujeme ako \u201eciviliza\u010dn\u00e9\u201c. Na z\u00e1klade kvantitat\u00edvnej anal\u00fdzy viac ako 5\u00a0000 anal\u00fdz v\u00fdsledkov krvn\u00fdch testov vykonan\u00fdch pomocou neinvaz\u00edvneho analyz\u00e1tora krvi AMP (nov\u0161\u00ed model ANESA) bolo nami zisten\u00e9, \u017ee pacienti, ktor\u00ed s\u00fa dlhodobo postihnut\u00ed dysbakteri\u00f3zou (dysbi\u00f3zou) v\u00a0anal\u00fdze vykazuj\u00fa zv\u00fd\u0161en\u00e9 hladiny vylu\u010dovan\u00e9ho oxidu uhli\u010dit\u00e9ho\u00a0<strong>CO<sub>2b\u00a0<\/sub><\/strong>z p\u013e\u00fac. Zv\u00fd\u0161en\u00e1 hladina\u00a0<strong>CO<sub>2b<\/sub><\/strong>\u00a0v krvi\u00a0sledovan\u00fdch pacientov sa odzrkadlila sprievodn\u00fdmi patol\u00f3giami ako s\u00fa: diabetes mellitus (T2DM), syst\u00e9mov\u00e1 hypertenzia, obezita, naru\u0161enie funkcie \u0161t\u00edtnej \u017e\u013eazy, bolesti hlavy (migr\u00e9na), syst\u00e9mov\u00e9 zvracanie alebo\u00a0krv\u00e1canie zo slizn\u00edc. Kvantifik\u00e1ciou pr\u00edznakov bolo zisten\u00e9, \u017ee po\u010detnos\u0165 v\u00fdskytu a rozsah patol\u00f3gi\u00ed u\u00a0dan\u00fdch pacientov je priamo \u00famern\u00fd jednak v\u00fd\u0161ke hladiny\u00a0<strong>CO<sub>2b<\/sub><\/strong>\u00a0v\u00a0krvi, ako aj samotnej dobe trvania dysbi\u00f3zy u pacienta. Mno\u017estvo\u00a0<strong>CO<sub>2m<\/sub>\u00a0<\/strong>produkovan\u00e9ho bunkami z\u00e1vis\u00ed priamo\u00famerne od mno\u017estva kysl\u00edka dodan\u00e9ho bunk\u00e1m, av\u0161ak mno\u017estvo tvorby\u00a0<strong>CO<sub>2c<\/sub><\/strong>\u00a0produkovan\u00e9ho\u00a0hrub\u00fdm \u010drevom je nekontrolovate\u013en\u00e9.\u00a0<strong>CO<sub>2c,<\/sub><\/strong>\u00a0produkovan\u00fd bakt\u00e9riami \u010driev a\u00a0hnilobn\u00fdmi procesmi teda zvy\u0161uje \u00a0celkov\u00fa hladinu CO<sub>2<\/sub>\u00a0v\u00a0krvi (<strong>CO<sub>2b<\/sub><\/strong>), \u010do\u00a0vedie k\u00a0vzniku mnoh\u00fdch patol\u00f3gi\u00ed u\u00a0\u010dloveka. Oxidom uhli\u010dit\u00fdm indukovan\u00e9 patol\u00f3gie s\u00fa priamo\u00famerne z\u00e1visl\u00e9 od rozsahu a doby trvania dysbi\u00f3zy (dysbi\u00f3za \u2013 naru\u0161enie rovnov\u00e1hy os\u00eddlenia hrub\u00e9ho \u010dreva bakt\u00e9riami). Nami nameran\u00fd zv\u00fd\u0161en\u00fd obsah CO<sub>2<\/sub>\u00a0v\u00a0krvi bol v\u017edy sprev\u00e1dzan\u00fd pr\u00edtomnos\u0165ou minim\u00e1lne jednej patol\u00f3gie uvedenej v\u00a0tabu\u013eke, \u010do viedlo k\u00a0vysloveniu nasleduj\u00faceho z\u00e1veru:\u00a0<strong><u>\u201enadmern\u00e1 pr\u00edtomnos\u0165 CO<sub>2<\/sub>\u00a0v\u00a0krvi vedie k\u00a0poru\u0161eniu rovnov\u00e1hy procesov z\u00fa\u010dast\u0148uj\u00facich sa na jeho tvorbe a\u00a0regul\u00e1cii.\u201c<\/u><\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f3dafbc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f3dafbc\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1117719\" data-id=\"1117719\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f5a8082 elementor-widget elementor-widget-text-editor\" data-id=\"f5a8082\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Ke\u010f sa bli\u017e\u0161ie pozrieme na patol\u00f3gie uveden\u00e9 v\u00a0Tab. 1 zist\u00edme, \u017ee ka\u017ed\u00e1 z\u00a0nich vedie k\u00a0zn\u00ed\u017eeniu tvorby metabolick\u00e9ho\u00a0<strong>CO<sub>2m<\/sub><\/strong>. Hlavn\u00fd chemoreceptor \u013eudsk\u00e9ho organizmu \u2013 karot\u00eddne teliesko, neust\u00e1le kontroluje hladinu kysl\u00edka (PO<sub>2<\/sub>) a H+\/CO<sub>2<\/sub>\u00a0\u00a0v\u00a0arteri\u00e1lnej krvi. Ve\u013ekos\u0165 neur\u00e1lneho sign\u00e1lu vyslan\u00e9ho karot\u00eddnym telieskom cez aferentn\u00e9 nervov\u00e9 vl\u00e1kna na hypotalamus je determinovan\u00e1 len koncentr\u00e1ciou [CO<sub>2<\/sub>] (H+\/CO<sub>2<\/sub>\u00a0). Karot\u00eddne teliesko nerozli\u0161uje p\u00f4vod CO<sub>2<\/sub>\u00a0t.j. \u010di CO<sub>2<\/sub>\u00a0je produktom\u00a0metabolick\u00fdch procesoch\u00a0<strong>CO<sub>2m\u00a0<\/sub><\/strong>alebo z\u00a0bakt\u00e9rialno-hnilobn\u00fdch procesov\u00a0<strong>CO<sub>2c\u00a0<\/sub><\/strong>. Neurosign\u00e1l karot\u00eddneho telieska m\u00e1 rovnak\u00fd charakter. Intenzita a\u00a0doba trvania sign\u00e1lu je priamo \u00famern\u00e1 len hladine\u00a0<strong>PCO<sub>2<\/sub><\/strong>\u00a0v\u00a0arteri\u00e1lnej krvi a\u00a0dobe trvania.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4ca8f84 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4ca8f84\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8a26f87\" data-id=\"8a26f87\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a2d396c elementor-widget elementor-widget-spacer\" data-id=\"a2d396c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.5 - 27-04-2022 *\/\n.e-container.e-container--row .elementor-spacer-inner{width:var(--spacer-size)}.e-container.e-container--column .elementor-spacer-inner,.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ce07b85 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ce07b85\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c71e7df\" data-id=\"c71e7df\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-65fc268 elementor-widget elementor-widget-heading\" data-id=\"65fc268\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-small\">Tabu\u013eka 1. Preh\u013ead patol\u00f3gi\u00ed indukovan\u00fdch zv\u00fd\u0161enou hladinou CO2 v krvi<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-21c1c81 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"21c1c81\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6da4f7d\" data-id=\"6da4f7d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4cb20d4 elementor-widget elementor-widget-image\" data-id=\"4cb20d4\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.5 - 27-04-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"579\" src=\"https:\/\/www.ncds.sk\/base\/wp-content\/uploads\/2022\/07\/table-1024x579.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ncds.sk\/base\/wp-content\/uploads\/2022\/07\/table-1024x579.jpg 1024w, https:\/\/www.ncds.sk\/base\/wp-content\/uploads\/2022\/07\/table-300x170.jpg 300w, https:\/\/www.ncds.sk\/base\/wp-content\/uploads\/2022\/07\/table-768x435.jpg 768w, https:\/\/www.ncds.sk\/base\/wp-content\/uploads\/2022\/07\/table-600x340.jpg 600w, https:\/\/www.ncds.sk\/base\/wp-content\/uploads\/2022\/07\/table.jpg 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9e0bdde elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9e0bdde\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-86667ff\" data-id=\"86667ff\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9e7f251 elementor-widget elementor-widget-text-editor\" data-id=\"9e7f251\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Ak mno\u017estvo CO<sub>2<\/sub>\u00a0v\u00a0krvi dosiahne kritick\u00fa hladinu, nast\u00e1va smr\u0165 organizmu (vn\u00fatrosyst\u00e9mov\u00e1 intoxik\u00e1cia \u2013 udusenie).<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9178a72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9178a72\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a81c932\" data-id=\"a81c932\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d72b788 elementor-widget elementor-widget-spacer\" data-id=\"d72b788\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Oxid uhli\u010dit\u00fd: induktor civiliza\u010dn\u00fdch patol\u00f3gi\u00ed. Jusko P., Onkocet Ltd., Bratislava, Slovakia, 5. november 2014\u00a0 PDF s\u00fabor: Pr\u00ed\u010dina vzniku patol\u00f3gie Diabetes Mellitus 2. typu.pdf Abstrakt: Oxid uhli\u010dit\u00fd: induktor \u201eciviliza\u010dn\u00fdch\u201c patol\u00f3gii. Bolo zisten\u00e9, \u017ee nadmern\u00e1 hladina CO2\u00a0v\u00a0krvi vedie k\u00a0poru\u0161eniu rovnov\u00e1hy procesov z\u00fa\u010dast\u0148uj\u00facich sa na jeho tvorbe a regul\u00e1cii, \u010do m\u00e1 za d\u00f4sledok vznik patol\u00f3gii ako je diabetes mellitus II. typu, syst\u00e9mov\u00e1 hypertenzia, obezita, naru\u0161enie funkcie \u0161t\u00edtnej \u017e\u013eazy, at\u010f. Pr\u00ed\u010dinou zv\u00fd\u0161enej hladiny CO2\u00a0v\u00a0krvi s\u00fa predov\u0161etk\u00fdm bakteri\u00e1lno-hnilobn\u00e9 procesy prebiehaj\u00face v\u00a0hrubom \u010dreve. V\u00a0\u013eudskom organizme oxid uhli\u010dit\u00fd (CO2) vznik\u00e1 z\u00a0dvoch baz\u00e1lnych procesov: metabolick\u00fd\u00a0CO2\u00a0(CO2m) v procese spa\u013eovania cukrov v\u00a0bunk\u00e1ch org\u00e1nov a\u00a0tkan\u00edv organizmu C6H12O6(aq)\u00a0+ 6O2(g)\u00a0\u2014\u2014\u2014-&gt; 6CO2(g)\u00a0+ 6H2O(l) +\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":193,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-320","page","type-page","status-publish","hentry"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":5}},"_links":{"self":[{"href":"https:\/\/www.ncds.sk\/base\/index.php?rest_route=\/wp\/v2\/pages\/320","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ncds.sk\/base\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ncds.sk\/base\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ncds.sk\/base\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ncds.sk\/base\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=320"}],"version-history":[{"count":5,"href":"https:\/\/www.ncds.sk\/base\/index.php?rest_route=\/wp\/v2\/pages\/320\/revisions"}],"predecessor-version":[{"id":328,"href":"https:\/\/www.ncds.sk\/base\/index.php?rest_route=\/wp\/v2\/pages\/320\/revisions\/328"}],"up":[{"embeddable":true,"href":"https:\/\/www.ncds.sk\/base\/index.php?rest_route=\/wp\/v2\/pages\/193"}],"wp:attachment":[{"href":"https:\/\/www.ncds.sk\/base\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=320"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}